Br J Obstet Gynaecol 94,387-402. It's the most common genetic chromosomal disorder and cause of learning disa… (1987) Estimating a woman’s risk of having a pregnancy associated with Down’s syndrome using her age and serum alpha-fetoprotein level. Compared to children without Down syndrome, children with Down syndrome are at higher risk for: Hearing loss (up to 75% may be affected) Obstructive sleep apnea, a condition where a person’s breathing temporarily stops while asleep (between 50 -75%) Ear infections (between 50 -70% may be affected) Eye diseases, like cataracts (up to 60%) Cuckle H. (1999) Down syndrome fetal loss rate in early pregnancy. Down syndrome is a genetic disorder caused when abnormal cell division results in an extra full or partial copy of chromosome 21. Cuckle HS, Wald NJ, Thompson SG. First-trimester or second-trimester screening, or both, for Down’s syndrome. Age-adjusted risk assessment for fetal Down’s syndrome during the second trimester: Description of the method and analysis of 142 cases. Enter your age below. Prenat Diagn 19,1177-1179. Because of the spontaneous miscarriages of pregnancies with Down syndrome between … Please insert a number. NIFTY® is a non-invasive prenatal test that screens for genetic conditions such as Down Syndrome with 99,5% accuracy form week 10 of pregnancy. Maternal Age Risk Calculator Back to all apps. It is known as the maternal age-specific risk and is the background risk of Down's syndrome used when interpreting a screening result. Ultrasound Obstet Gynecol. Nyberg DA, Luthy DA, Resta RG, et al. The incidence of fetal trisomies is directly related to maternal age. 2005;353:2001-2011. 1998;12:8-14. Please insert maximum age of 50. Please insert minimum age of 16. The risk of having a term pregnancy with Down's syndrome increases with maternal age as shown in the table below. These include: Advanced maternal age (a woman over the age of 35) Advanced paternal age (a man over the age of 40) A previous pregnancy with a down syndrome foetus (carried full term or miscarried). This is the same as saying that the baby has a 1 percent chance of having Down syndrome and a … N Eng J Med. This extra genetic material causes the developmental changes and physical features of Down syndrome.Down syndrome varies in severity among individuals, causing lifelong intellectual disability and developmental delays. For example, a risk of Down syndrome of one in 100 means that if 100 women have this risk, we expect that one of these women will have a baby with Down syndrome and that 99 will not.